Fails out to get spectre meltdown10/31/2023 To get all available protections, firmware (microcode) and software updates are required. Microsoft has released updates to help mitigate these vulnerabilities. We advise customers seek guidance from their respective vendors. Important: These issues will affect other systems such as Android, Chrome, iOS, and MacOS. They have been assigned the following CVEs:ĬVE-2018-11091 – “Microarchitectural Data Sampling Uncacheable Memory (MDSUM)”ĬVE-2018-12126 – “Microarchitectural Store Buffer Data Sampling (MSBDS)”ĬVE-2018-12127 – “Microarchitectural Fill Buffer Data Sampling (MFBDS)”ĬVE-2018-12130 – “Microarchitectural Load Port Data Sampling (MLPDS)” On May 14, 2019, Intel published information about a new subclass of speculative execution side-channel vulnerabilities known as Microarchitectural Data Sampling. Note: We recommend that you install all of the latest updates from Windows Update before you install any microcode updates. For more information about L1TF and recommended actions, see our Security Advisory:ĪDV180018 | Microsoft Guidance to mitigate L1TF variant L1TF affects Intel® Core® processors and Intel® Xeon® processors. On August 14, 2018, L1 Terminal Fault (L1TF), a new speculative execution side channel vulnerability was announced that has multiple CVEs. For more information about this vulnerability and recommended actions, see the following Security Advisory:ĪDV180016 | Microsoft Guidance for Lazy FP State Restore On June 13, 2018, an additional vulnerability involving side-channel speculative execution, known as Lazy FP State Restore, was announced and assigned CVE-2018-3665. įor more information about these vulnerabilities, see the resources that are listed under May 2018 Windows operating system updates, and refer to the following Security Advisories:ĪDV180012 | Microsoft Guidance for Speculative Store BypassĪDV180013 | Microsoft Guidance for Rogue System Register Read The customer risk from both disclosures is low. On May 21, 2018, Google Project Zero (GPZ), Microsoft, and Intel disclosed two new chip vulnerabilities that are related to the Spectre and Meltdown issues and are known as Speculative Store Bypass (SSB) and Rogue System Registry Read. You can learn more about these vulnerabilities at Google Project Zero. This class of vulnerabilities is based on a common chip architecture that was originally designed to speed up computers. On January 3, 2018, Microsoft released an advisory and security updates related to a newly-discovered class of hardware vulnerabilities (known as Spectre and Meltdown) involving speculative execution side channels that affect AMD, ARM, and Intel processors to varying degrees. Specific vulnerability details for these silicon-based issues can be found in the following security advisories and CVEs:ĪDV180002 - Guidance to mitigate speculative execution side-channel vulnerabilitiesĪDV180012 - Microsoft Guidance for Speculative Store BypassĪDV180013 - Microsoft Guidance for Rogue System Register ReadĪDV180016 - Microsoft Guidance for Lazy FP State RestoreĪDV180018 - Microsoft Guidance to mitigate L1TF variantĪDV190013 - Microsoft Guidance to mitigate Microarchitectural Data Sampling vulnerabilitiesĪDV220002 - Microsoft Guidance on Intel Processor MMIO Stale Data VulnerabilitiesĬVE-2022-23825 AMD CPU Branch Type Confusion It also provides a comprehensive list of Windows client and server resources to help keep your devices protected at home, at work, and across your enterprise. This article provides information and updates for a new class of silicon-based microarchitectural and speculative execution side-channel vulnerabilities that affect many modern processors and operating systems. Removed a duplicated topic titled "Intel microcode updates" in the "Steps to help protect your Windows devices" section Removed content about CVE-2022-23816 as the CVE number is unused
0 Comments
Revolvr mens10/31/2023 Albania Andorra Anguilla Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belgium Belize Benin Bermuda Bolivia Bosnia and Herzegovina Botswana Brunei Bulgaria Burkina Faso Cambodia Canada Cape Verde Cayman Islands Central African Republic Chile China Colombia Comoros Congo Cook Islands Costa Rica Croatia Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Estonia Fiji Finland France French Guiana Gabon Georgia Germany Ghana Gibraltar Greece Greenland Guadeloupe Guatemala Guernsey Guinea Haiti Honduras Hong Kong, China Hungary Iceland Ireland Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kuwait Kyrgyzstan Laos Latvia Lebanon Libyan Arab Jamahiriya Liechtenstein Lithuania Luxemburg Macao, China Macedonia, Republic Of Malawi Malaysia Maldives Mali Malta Martinique Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Namibia Nepal Netherlands New Caledonia New Zealand Nicaragua Nigeria Norway Oman Pakistan Panama Papua New Guinea Paraguay Peru Philippines Poland Portugal Qatar Republic of Cameroon Reunion Romania Rwanda Saint Kitts And Nevis Samoa San Marino Saudi Arabia Senegal Serbia Seychelles Singapore Slovakia Slovenia South Africa South Korea Spain Sri Lanka St. Role: REVOLVR Menswear - Store Manager Reports to: District Manager Starts: April 2021 Were looking for our next leader at REVOLVR Menswear in Portland, Oregon slated to open May/June 2021 Seeking a self motivated, highly organized, and enthusiastic Store Manager to lead our team. Play station merch10/31/2023 Turn it on, and it will light up when you drink from it!Īvailable for pre-order. Illuminate your day with this bottle designed with the DualSense wireless controller in mind. Price: USD$229.95* Ships to US, Canada, and other select countries** With a sleek and clean style, coming in at 18 inches x 11 inches, it’s a great bag to pack your necessities on the go.Īvailable for pre-order. This backpack pays homage to the unique PS5 console design. Keep warm with our new beanies! There are a couple styles to choose from, each with its own unique PlayStation flair. Ships to US, Canada, and other select countries**ĭebossed DualSense Wireless Controller Beanie Price: USD$79.95* Ships to US, Canada, and other select countries**Īvailable for pre-order. Don’t worry, it comes in both men’s and women’s fit to match your comfort needs.Īvailable for pre-order. Price: USD$179.95* Ships to US, Canada, and other select countries**įan of joggers? These new PS5 console inspired joggers are accented with a custom DualSense wireless controller line art pattern at the knee. We’re excited to launch this new style for you to enjoy.Īvailable for pre-order. This Bomber Jacket comes in both men’s and women’s fit. Not only that, the inside lining has a custom line art pattern inspired by the DualSense wireless controller. Our last bomber jacket was a fan favorite, so we brought back the bomber silhouette and outfitted it with a thicker quilted pattern to keep you warm this winter. Right out of the gate, we want to reveal our custom PS5 console inspired Quilted Bomber Jacket. Let’s take a quick look at some of the new PS5 branded items you’ll find on the PlayStation Gear store today. We’ve been hard at work curating products to fit your everyday lifestyle, and we can’t wait for you to see what we have in store for this launch. It seems to be primarily aimed at accidental purchases, faulty products or change of mind for digital preorders, though there is a level of ambiguity around the restrictions so if uncertain it’s probably worth contacting PlayStation support anyway.PlayStation Gear is excited to announce our first PS5 branded merchandise. It’s important to note that the terms state clearly that no refunds are offered once content has been downloaded, unless it’s ‘faulty’, meaning this won’t help you if you simply don’t like a game that you’ve purchased. You can cancel your purchase of a season pass within 14 days from the date of purchase and receive a refund to your PSN wallet, provided that you have not started downloading or streaming any digital content ( e.g. game add-ons) included in the season pass. You can cancel a digital content purchase within 14 days from the date of purchase and receive a refund to your PSN wallet, provided that you have not started downloading or streaming it.ĭigital content that you have started downloading or streaming, and in-game consumables that have been delivered, are not eligible for a refund unless the content is faulty. Where before, digital PlayStation content purchases were offered on a pretty rigid ‘no refunds’ basis (save for whatever ‘goodwill’ one could coax out of their call centres), a new policy as outlined in the ToS now states as follows: The PlayStation Store has long been one of the last bastions of thoroughly outmoded and downright anti-consumer refund policies for digital content, but that finally changes (slightly) today. Juicebox prophoto10/31/2023 (You would need to know exact heights for all elements on your web page and use JavaScript and the Juicebox-Pro API to resize the gallery to fit within the remaining space.) What you are looking to do would certainly be possible but very difficult to achieve (if at all possible) within a WordPress environment. You could reduce the height of your gallery but this would not guarantee that the entire gallery would be seen without scroll bars in every possible size and shape of browser window. it stills scrolling and i dont want that.Ī WordPress page is not designed to fit everything into a browser window vertically without the need for scroll bars.Ī WordPress page will typically just display the content of the page (in a vertical list style) and the browser will display scroll bars if necessary. Try viewing your gallery's web page in different browsers (Mobile Chrome, Mobile Firefox and Mobile Safari) to see if the problems are unique to certain browsers. Please also let me know what mobile devices and browsers you see the problems in (and what operating systems the mobile devices are running). If you continue to experience difficulties, then please post the URL to your gallery's web page so that I can take a look and investigate further. You have no control over the size of the browser window being used to view your web page (and your gallery) so it would be very difficult to guarantee that no scroll bars are required (unless you have the gallery on a page of its own with dimensions of 100% x 100%, which is what happens when expanding the gallery from the Splash Page). If you don't use the Splash Page, then the gallery will be embedded in your page at the dimensions you set via galleryWidth and galleryHeight. B)or if i dont use the splash Page how to avoid scrolling when it loads this first thumb photo? Nighttime habits of successful people10/31/2023 Even when it’s something you should be doing, success rates are incredibly low. It can be difficult to develop new habits on demand, even if you know the habit is positive and useful. Ask Yourself, ‘Why Do You Want To Do This?’ “Both of these hormones are responsible for happiness, will help you feel more energized during the day and you’ll be able to think more clearly,” said McKey.Ħ. By working out, your body releases serotonin and endorphins. One reason: exercise reduces your stress levels, which in turn helps combat insomnia. Indeed, studies have shown a strong correlation to a better quality of sleep for people who work out at least 10 minutes a day. “People who exercise tend to sleep better than those who don’t,” said Vanderkamp. McKey’s own reward is to see the sunrise, which is why she jogs early in the morning. Find a little bit of that magical motivation: Think of something you want to do, but can never find the time to do, whether it’s playing with your cat, catching up with a friend or enjoying a home-cooked breakfast. “Every kid is a morning person on Christmas day,” said Vanderkamp. Similarly, have a reward in mind for why you want to wake up early. “This way you’ll feel like you’re on a mission when you wake up, you’ll get closer to your morning goal and you’ll have a clear schedule to follow.” Seeing the benefits of your earlier wake-up time (like feeling less overwhelmed when you arrive at work) will make it feel less like a chore. She recommends writing three tasks you have to do the next day. “Having a morning goal is the best motivation,” said McKey. Paying bills or checking your child’s schoolwork could induce more stress than watching a comedy that sends you off to bed with a smile.Īnother good habit is to think about what you want to accomplish in the morning. “Think about what gets you going and has your mind racing and avoid it.” Reading is a great way to unwind and relax, but reading a thriller may not be the best idea. “It’s really an individual thing,” said Vanderkamp. And contrary to popular advice, you don’t have to turn off screens right before bed. To be successful in sticking with an earlier bedtime, you may need to set an alarm to start winding down. Nighttime can slip away fast, especially when you have a lot to accomplish. If that’s the case, think about a time you’ve been on vacation or of a night you felt particularly rested - how much sleep did you get? Once you have that number, count backwards from the time you want to get up and plan to go to bed at that new hour. In reality, babies, work projects or a “Sherlock ” marathon can make this exercise laughable. Divide that number by seven to calculate your nightly need. Here’s how to figure out your sleep needs: For a week, track the number of hours you sleep, including weekends. But that number can be drastically different for everyone. The easiest way to wake up earlier in the morning is to get enough sleep. We partnered with Tropicana and talked to experts about the best tips and tricks to follow to help you make the most of your mornings. meeting, everyone notices.” In other words, no one sees how much energy you have or how hard you’re working at 11 p.m.īut here’s the good news: It’s possible to seize the day and develop morning-person habits, even if your genes say otherwise. And in the workforce, if you’re on top of your game at an 8 a.m. While our lifestyle habits and personality traits contribute to our preferred sleep routines, it’s the genes of early birds and night owls that determine what time of day they are most alert, explained Zoe McKey, author of Daily Routine Makeover-Morning Edition.ĭoes it matter if you’re a morning person or a night owl? “The world is oriented toward rewarding morning people,” said Laura Vanderkamp who is the author of What the Most Successful People Do Before Breakfast: “Research has shown that students who are alert in their morning classes get better grades. C) Toss the covers off with glee and start your day. Pop quiz: How do you react when your alarm goes off? A) Hit the snooze button a half dozen times. Jira vs asana vs monday10/31/2023 Keep track of them through lists, timelines, or the board view. You can also choose to delete some columns of information if it’s overwhelming.Īsana lets you create tasks, set their goals and deadlines, create dependencies, and assign them in a few seconds. In fact, with Monday, you can see the team, owners, timelines, status updates (color-coded), and progress for each task. However, Monday can show more information at a glance. Task managementĪsana has been known to offer faster task creation as it doesn’t require as many details to create as Monday. * Paid has the feature, but is only available under paid plans. Let’s see who pulls out on top in this Asana vs Monday showdown: In this section, we highlight the features of each tool and break them down to help you determine which is the best for your specific needs. : Comparing Core FeaturesĪlthough the platforms are similar, each tool has differences in features and functionality that give both their project management benefits. Ultimately, the tools are suitable for different organizations and needs, which is why it’s important to know the core features. Users can get a task list view across all projects on Monday Asana Vs. Let’s dig into each platform, discuss the pros and cons, and cover all the features of the two project management software options in our Asana vs. So back to the main question-what’s better: Asana or Monday? And luckily for businesses, there are plenty of options to manage, track, and plan projects with their team. It facilitates the workflow of the team working on the project and allows project managers to actually handle all of those projects-effectively. Wizards are pretty cool, but project management software is absolutely ideal for anyone needing to plan projects, assign and schedule tasks, allocate resources, and track deadlines. There’s some serious wizardry happening, or more likely than not, organizations are relying more on cloud-based project management software. With so many organizations switching to a distributed workforce, how do they manage multiple projects at the same time? But which platform goes above and beyond its competitor?įor starters, all successful projects, irrespective of magnitude and objective, have one thing in common: proper management and team collaboration. Monday – it’s a question we hear all the time. Glitch overlay photoshop action10/31/2023 Each sans serif letter has been individually distorted in stages, using detailed high resolution effects. It’s in the form of horizontal pieces like glitch effect. Click now to create a custom image with your own words that you can download.Beauty Glitch Font is a sans serif type of bold and italic type. Released in 2018 by CloutierFontes and licensed for personal-use only. Click now to create a custom image with your own words that you can download.Free download of CF Glitch City Font. Released in 2021 by Billy Argel Fonts and licensed for personal-use only. Click copy to copy your favorite text font.Free download of Blue Screen Font. Now just Click on the "copy" button beside the font you want to copy to copy the text. Type your text in the input area, and you will see that all the fonts for your generating live. Making the web more beautiful, fast, and open through great typographyHow to use. Invoke the Nezperdian hive-mind of chaos. Fancy fonts work on Facebook, TikTok, Twitter, Discord, Instagram, YouTube, Zoom, Steam, Tumblr. Copy and paste the desired font into any text box around the web. After you do that, the converted text will appear in the box on the right. How to use font generator? To use this font generator, simply type or paste text into the box to the left. Cynatar Font is a sci-fi cyber font inspired by futuristic styles. Perfect for futuristic design, the font template is stylish and super cool.
Ll bean bedding duvet covers twin10/30/2023 OEKO-TEX 100 …Bedsure 100% Cotton Blankets Queen Size for Bed - 405GSM Waffle Weave Blankets for Summer, Cozy and Soft Woven Blankets, Lightweight Fall Blankets, White, 90x90 Inches. A premium product, extremely soft and luxurious. Forearm Forklift Full Size-2 Color Moving Blanket.Check out our 100 cotton blankets selection for the very best in unique or custom, handmade pieces from our shops.Premium knitted waffle Blankets with yarn-dyed 100% Cotton yarn. Stalwart Moving Blankets Dual Layer Padded. Sure-Max Heavy-Duty Moving & Packing Blankets - Ultra Thick Pro. Cat Non-Woven Utility Padded Protection Moving Blankets. US Cargo Control Supreme Mover Moving Blankets. Cheap Cheap Moving Box - Moving Blankets. Lovey 100% Cotton Blanket with Satin Border, 20" x 20", White waffle cotton, Mini Eco - Morgan Infant Baby Child Blanket, Handmade in Iowa. Check out our 100% cotton baby blanket selection for the very best in unique or custom, handmade pieces from our shops. Best Cooling Weighted Blanket Sleep Number True Temp Weighted. Best Cotton Weighted Blanket Silk & Snow Hand Knitted Weighted Blanket.Plus, it’s offered in multiple sizes and colors, so you’ll be able to find one that suits your space.Check out our 100%cotton blanket selection for the very best in unique or custom, handmade pieces from our blankets & throws shops.Knitted Baby Blanket, 100% Cotton, Hand Knit Baby Blanket, Baby Shower Gift Idea, Newborn blanket, White Super Soft Blanket, Nursery Decor (3) $ 68.22Sep 6, 2023 The Company Store’s Merino Wool Pinstripe Blanket is the best wool blanket to upgrade your bedroom. Unbeatable p.Product Details: Size: From 66 x 84 inches | Wool and cotton |. 100 cotton blanket 100 cotton blankets Shop 100% Cotton Hotel Blanket Thermal Herringbone White King 110 inch x 90 inch. Best Contemporary Interior design images Interior. Lightweight Summer Blanket for Hot Sleepers, Breathable Skin-Friendly Waffle Blanket(White, 108×90in) Best Gift Idea. Best Even Distribution: Bare Home Weighted Blanket.Tex Trend Luxury 100% Cotton Blanket - Soft Blankets Queen Size for Bed, Sofa & Couch - Breathable Blanket for Summer - All Season Cotton Thermal Blanket (Mustard, Queen). Best Cotton: ZonLi Cooling Weighted Blanket. Best Value: Syrinx Cooling Weighted Blanket. Best Overall: Luna Bamboo Weighted Blanket. Browse through this list of the best cooling weighted blankets-all under $80-that have expert-approved features and are loved by shoppers on Amazon. Luxury Thermal Cotton Blankets, King Size- Light Blue. COTTON CRAFT Soft Cotton Thermal Blanket - Plush Herringbone Twill -.Vellux 100% Cotton Blanket - Soft, Breathable, Cozy & Lightweight Thermal Blanket - All Season Queen Size Blanket Perfect for Layering Bed, Couch & Sofa - Hotel Quality (90x90 Inch Light Grey). Code USALOVE can be used at checkout for 15% off your purchase.Cotton is a fabric that has many great qualities and is popular for a number of reasons, the first of which is that it is an incredibly soft fabric! Moreover, cotton becomes softer each time you wash the material! It is also suitable for almost all types of weather. They also come in a variety of sizes for kids, teens, and adults. Best seller.These weighted blankets are available in 100% Cotton (the most popular), Minky (perfect for sensory feeling), COOLMAX (for hot sleepers), and waterproof hospital fabric. NTBAY 100% Pure Cotton Cable Knit Throw Blanket, Super Soft Warm Knitted Throw Blanket for Couch, Sofa, Chair, Bed - Extra Cozy, Machine Washable, Comfortable Home Decor, 51"圆7", Navy Blue. Sizes: 64 x 88 inches | Colors: 7 | Material: 80% wool, 20%. The detailed double stitching, softness, coloring and thickness of the blanket, all speak volumes-truly a high quality product.”. Best Cotton Blanket Pattern – Exclusivo Mezcla Luxury Reversible 100% Cotton Paisley Quilted Bed Blanket. Best Cotton Blanket Bargain – Utopia Bedding Premium Cotton Blanket. Best Cotton Waffle Weave – PHF Cotton Waffle Weave Bed Blanket. Editor’s Pick – Cotton Craft 100% Soft Premium Cotton Thermal Blanket. Look up vin number info10/30/2023 Using the license plate is the easiest way to verify the registration details of a vehicle, including its make, model, year of manufacture, vehicle’s vehicle identification number (VIN) and other relevant information. Vehicle verification and identification are important steps for any car owner or buyer. How to Use a License Plate Lookup for Vehicle Verification & Identification If you want to choose the letter/number combination, you may order custom license plates or vanity plates. city government, the federal government, and some Native American tribes issue special license plate numbers. Most states have their own distinctive color scheme, logo, and registration number format for license plates. To identify the vehicle, the plate is mounted on the front and rear or at the rear of the vehicle. They come in a variety of shapes, sizes, and designs, and can be personalized or customized to fit the needs of the vehicle owner. This unique number is embossed or surface-printed on a metal or plastic plate. The state DMV assigns the license plate or registration number to a vehicle upon registration. By entering the license plate number into the search field, users can get access to detailed records about a vehicle in just seconds. License plate lookup services are also used by law enforcement agencies, private investigators, insurance companies, and even individuals who want to check on the background of a car they are considering buying. With a more advanced vehicle research tool, you can buy the car you want with confidence. In 2021, used car sales in the United States hit an all-time record with 40.9 million units sold. Over the years, pre-owned car sales have exceeded new car sales. Getting a vehicle history report before buying helps you make a more informed decision about whether or not to purchase it. Part 583.What is a License Plate Lookup and How Does It Work?Ī license plate lookup tool allows users to search for information about a vehicle using its license plate number. In addition, more information may be available on a label affixed to the vehicle. If you have further questions regarding this information, please contact the vehicle manufacturer. Note: The information displayed through the VIN decoder is reported by the manufacturer. Step 2: Refer to the field at the bottom of the page result, which expressly lists the build plant and country for the searched vehicle. Step 1: Go to and enter the full VIN into NHTSA’s VIN decoder, then click Decode VIN. After searching a VIN, you'll see the build plant and country for the vehicle in question. Using NHTSA's VIN Decoder to Identify a Vehicle’s Plant of ManufactureĪmong the information NHTSA's VIN decoder provides is information about the vehicle’s plant of manufacture. NHTSA’s VIN decoder is publicly accessible at. On, you can query a particular vehicle’s VIN to identify specific information encoded in the number. Under NHTSA’s regulations, each motor vehicle must contain a vehicle identification number, also known as a VIN, which is a 17-character number that encodes specific information about the particular vehicle. As part of our mission, NHTSA develops certain standards for motor vehicle safety and reporting. The National Highway Traffic Safety Administration is an operating administration of the United States Department of Transportation and is the federal agency responsible for improving motor vehicle safety on United States roadways. Mitochondrial fission and fusion10/30/2023 This phenomenon, known as the Warburg effect or aerobic glycolysis, facilitates tumour growth with elevated glucose uptake and lactate production. 14Ĭancer cells exhibit aberrant metabolism characterised by high glycolysis in the presence of abundant oxygen. 12, 13 For HCC cells, mitochondrial fission was positively related to their metastatic capacity via modulating calcium homoeostasis. 11 Increased mitochondrial fission was reported to promote the survival of HCC cells by facilitating autophagy and inhibiting mitochondria-dependent apoptosis. 10 In addition, marked upregulation of DNM1L expression was reported to promote breast cancer metastasis via enhancing mitochondria fission. 8, 9 Recent studies showed that lung cancer exhibited excessive mitochondrial fission and impaired mitochondrial fusion due to an imbalance of DNM1L/MFN expression, which is important for cell cycle progression. 7 Several studies have reported dysregulated expression of mitochondrial dynamic proteins such as dynamin 1 like (DNM1L), mitofusin-1 (MFN1) and mitofusin-2 (MFN2) in lung, colon and breast cancers. Mitochondrial dysfunction is closely related to tumorigenesis and tumour progression, where mitochondrial dynamics plays a pivotal role. Morphologically, the mitochondrial network is characterised by a mixed structure of long interconnected tubules with short isolated dot-like spheres, which is precisely regulated by two opposite processes: fusion and fission. 4, 5 Mitochondria exist as a dynamic network that constantly changes the morphology to meet the energy demand of cells and to adapt to the extracellular environment. 3 Mitochondria are bioenergetic, biosynthetic and signalling organelles that are critical for multiple cellular functions including growth, division, calcium homoeostasis, energy metabolism and apoptosis. 2 Therefore, a new perspective of tumour metastasis mechanism in HCC is urgently needed, which may help to identify potential targets and develop effective therapies for HCC patients.Īccumulative evidence suggests that mitochondria is an important mediator of tumorigenesis and tumour progression. 1 Despite significant progress in HCC treatment, the prognosis of HCC patients is still far from satisfactory, mainly resulting from early metastasis and recurrence. Almost 50% of newly diagnosed HCC cases occur in China. Hepatocellular carcinoma (HCC) is one of the most common human malignancies and the second leading cause of cancer-related mortality worldwide. MFN1 may serve as a novel potential therapeutic target for HCC. Our results reveal a critical involvement of mitochondrial dynamics in HCC metastasis via modulating glucose metabolic reprogramming. Treatment with glycolytic inhibitor 2-Deoxy- d-glucose (2-DG) significantly suppresses the effects induced by depletion of MFN1. Moreover, MFN1 modulates HCC metastasis by metabolic shift from aerobic glycolysis to oxidative phosphorylation. Mechanistically, disruption of mitochondrial dynamics by depletion of MFN1 triggers the epithelial-to-mesenchymal transition (EMT) of HCC. While promoting mitochondrial fusion, MFN1 inhibits cell proliferation, invasion and migration capacity both in vitro and in vivo. Among genes involved in mitochondrial dynamics, MFN1 is identified as a leading downregulated candidate that is closely associated with HCC metastasis and poor prognosis. High metastatic HCC displays excessive mitochondrial fission. Mitochondrial dynamics, represented by constant fission and fusion, are found to be associated with HCC metastasis. The effects and underlying mechanisms of MFN1 on HCC metastasis and metabolic reprogramming are analysed both in vitro and in vivo. The mitochondrial fusion protein mitofusin-1 (MFN1) expression and its prognostic value are detected in HCC. However, how these dynamics integrate tumour metabolism in hepatocellular carcinoma (HCC) metastasis is still unclear. Mitochondrial dynamics plays an important role in tumour progression. AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |